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Writer's pictureTaylor Ann Drew

Weight Loss with GLP-1 Receptor Agonists

GLP-1 (Glucagon-Like Peptide-1) is a hormone that plays a role in regulating blood sugar levels and also has effects on appetite and weight regulation. Here's some information about GLP-1 and its role in weight loss for patients:


1. Natural Function: GLP-1 is produced in the intestines in response to food intake. It stimulates the release of insulin from the pancreas, which helps lower blood sugar levels after meals. Additionally, GLP-1 slows down gastric emptying and promotes feelings of fullness, which can help control appetite and reduce food intake.

2. GLP-1 Receptor Agonists: Medications called GLP-1 receptor agonists mimic the action of GLP-1 in the body. These medications are used to treat type 2 diabetes by helping to lower blood sugar levels. They have also been found to promote weight loss in people with and without diabetes.

3. Mechanism of Weight Loss: GLP-1 receptor agonists promote weight loss through several mechanisms:

- They reduce appetite by acting on the brain to increase feelings of fullness and reduce cravings.

- GLP-1 receptor agonists slow down gastric emptying, which can help people feel fuller for longer periods after eating.

- These medications may also increase the body's energy expenditure, leading to the burning of more calories.

4. Benefits for Weight Loss: Studies have shown that GLP-1 receptor agonists can lead to significant weight loss in individuals with obesity or overweight, both with and without type 2 diabetes. The amount of weight loss varies from person to person but can be substantial over time.

5. Medications: Examples of GLP-1 receptor agonists used for weight management include tirzepatide and semaglutide. These medications are administered as a once-weekly injection.

6. Side Effects: Common side effects of GLP-1 receptor agonists may include nausea, vomiting, diarrhea, and occasional injection site reactions. These side effects are usually mild and tend to improve over time as the body adjusts to the medication.

7. Precautions: GLP-1 receptor agonists are generally well-tolerated, but they may not be suitable for everyone. Patients with a history of pancreatitis, thyroid cancer, or multiple endocrine neoplasia syndrome type 2 (MEN 2) should discuss the risks and benefits of GLP-1 receptor agonists with their healthcare provider.

8. Consultation: If you are considering using a GLP-1 receptor agonist for weight loss, it's important to consult with a licensed healthcare provider. Your provider can provide guidance on whether this type of medication is appropriate for you, discuss potential side effects, and help you develop a comprehensive weight loss plan tailored to your individual needs.


In summary, GLP-1 receptor agonists can be effective tools for promoting weight loss in individuals with obesity or overweight, but they should be used under the supervision of a healthcare professional and as part of a comprehensive weight management plan that includes diet, exercise, and behavioral changes.

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